Really wish they would screen blood for this when someone donates, it is scary for women to have to go thtough this. Could you respond by email too because I don’t think I could find this feed again if I tried . Now, we’ve all met families where all the kids were the same gender, so you know 50/50 doesn’t mean it will always split down the middle between two outcomes. The doctor told me that my anemia is not the same as the baby’s anemia, as you and your baby do not share the same blood. 90% of the population is Kell negative. It is actually very rare to develop these antibodies, even if your husband is kell positive and you are kell negative. I really REALLY hope that modern medical intervention keeps you and your current baby healthy. Or would the kell positive woman still need medical advice/help to conceive and carry to term? 1. I hope the information I sent via Facebook chat will help. I phoned the midwife to enquire and was told she made a clerical error, no antibodies in my blood. Quelles sont les caractéristiques du sang qui déterminent notre rhésus ? I didn’t really understand it at the time but I was told something about other blood groups (m-/n-?). It sounds like everything will be good, though, so try to stay calm. Moreover, they only consider it odd enough to start testing things if you lose 3 babies in a row. The best news is that there is a lot they can do nowadays to keep a Kell+ fetus healthy until birth. Advice… Other articles have told me that the antigen is very common, while the antibody is not so much. I love my wife and my kids, regardless of their origin. Thank you for the advice Kyra! My wife is pregnant with our fourth child and has had three prior C Sections. Everyone would have two of these genes, so people with Kell positive blood are either “KK” or “Kk”, and people with Kell negative blood are “kk”. But a problem can occur when a Kell-negative mom is somehow exposed to the Kell-positive blood — say, via a blood transfusion. If mom’s brown eyes are Bb, then some of the kids might be blue-eyed, but the brown-eyed kids are all going to be carrying a recessive too. Well I am 13 weeks pregnant now, and I just was informed by my doctor that I have the anti-kell antigan. Thanks for your help! Your little girl must be Kell+ and #9 must be Kell+ or your body would not be making antigens. (Sadly, two losses in a row are common; docs don’t usually ‘worry’ until the third.) so far the doctors are thinking that i got this anti-body from the transfusions since we r still waiting on my husbands blood test from last week. What I am also wondering is are the Kell antibodies only detectable if the baby in fact has the antigen, or are they detectable even when basically dormant. But a problem can occur when a Kell-negative mom is somehow exposed to the Kell-positive blood — say, via a blood transfusion. f. ferron52 @RnJess13, Thank you for responding. I hope your pregnancy is a very, VERY healthy one with no complications. The #1 explanation for unknown antibodies is a false positive test or clerical error. As for the next pregnancy … luck will play a big part of it. Also I think maybe some people are getting g mixed up on this sight. I’m trying to understand what it means that I’m K+k+. This is such a scary thing. Wait another 3 weeks…. Okay, the odds that your bloodwork gave a false negative is MUCH higher than the odds of any kids being not yours. Thus, all four  children could be kk and Kell positive blood would disappear from their genetic line. The B Positive blood type is extremely valuable where matching supply for the demand has been a constant challenge. The antibodies are usually made after a blood transfusion.. I have been wondering if the tables could be turned, could the father produce a K positive baby and mom be k negative. To have Kell positive blood means you have at least one of the Kell antigens on your red blood cells. Une personne estrhésus positif (+)si ses globules rouges portent, à leur surface, une certaine molécule, appelée molécule rhésus. This is assuming the blood tests are all correct. Dominate browns can easily be hiding secret blue genes (insert blue jean joke here) but the brown B is gone once the recessive have the field. I’m assuming in your terminology its KK, and the typical K-k+ from 23andMe is kk? But in some breast cancers, the HER2 gene produces too many proteins. I’m 35 weeks and have slight anemia as I did with my 1st baby. That’s where antigens are located in the red blood cells. Thank you very much, I had quite the scare and was so mad about the whole thing . Years later they had another child, also Kk. I sincerely hope all of your subsequent pregnancies bring you such joyful results as well! (adsbygoogle = window.adsbygoogle || []).push({}); Post was not sent - check your email addresses! It is rare my midwife said to find blood compatible with Kell. I have the antibody and my husband is Kell positive (I formed the antibodies from my first born.). And yet, 38 years later, here I am. I got really sick with a rare blood disease and had to deliver the babies at 18 weeks (worst thing I have ever done). I almost died having my son. Of course, all of them could have brown eyes – it depends on the roll of the genetic dice when Mr. Forgot to post this; my apologies for the delay). the baby has kell positive plus anti kell antibodies? I have read a few articles on kell but must have my blonde head on as I can’t get my head round it. Kell is not a blood type; it is one (among many things) that attaches to some peoples blood cells. I wonder if my blood type is actually a connector, although according to the heredity patterns, could the Kk have survived through a father line? This means we can use the Punnett square again and see the genotypes of the offspring of a brown-eyed person (BB or Bb) and a blue-eyed person (bb). My doctor explained my problem to my husband and I, where I cried until his results came back negative. At that time the MFM usually would do an MCA to check to see if baby appears anemic before the results come back as transfusions can happen as early as 16 wks. I have a 3 year old daughter and my blood test was negative for anti kell antibodies when I had her. I am still confused by this, after I had my first born (daughter) I went to donate blood and was sent a letter that stated there was not a need for my blood type, when I became pregnant with my son I had to go through a amiosenthesis and had a very straining pregnancy. And generally, that’s not a problem. Egg. However, if the baby before this current pregnancy was Kell positive, now your body has become “allergic” to any Kell positive fetus and will attack your baby. You cannot have both. Hi Kyra thanks for replying. I am in the same boat as this woman above. I hope I explained why your last healthy baby could have been unknown Kell positive adequately? Inheritance Patterns. I sincerely appreciate your consideration. It is fairly certain Mary’s son cannot be Henry’s (the dates the king was near here don’t match up). I have Read your article a couple times and as a Mother with Kell antibodies, 2 Kell positive girls, your 150 years is extreme. Hi I have 8 children when I was 20 weeks pregnant with baby number 9 they told me I had kell antibodies and during delivery some of my daughters blood must of leaked back into my system to create antibodies , my husband is father to all my children so is it just pure luck we haven’t had any issues till now? My family scared my and they want me to turn that marriage off, because of the effects of taking “immune globulin intravenous”!! But my levels of it were too weak to show up on the titer level. They have lots they can do for alloimmunization nowadays, and will be even better in the future I hope, so there is no reason to stress this far away from game day . (I have found that most doctors and blood centers don’t check for this because it is so rare.) helloo, So if every boy grew up, married, and had 4 kids himself … then no more than 4 out of the 16 grandchildren could possibly have the Kell positive gene. Something that drew me to this article is that my last name is Cary, as in Mary Boleyn Cary, mistress of Henry VIII. A very simplified version of how a dominate gene (especially one that is harmful under certain conditions) can wind up being in only a small minority of a population. If you and the father and both kell neg then your child will be kell neg. Download The Appto explore more tools like Planner+ and Food Safety. We did not know anything about this until we were tested for genealogy purposes and I only tested two of my sons, so it would behoove us to get everyone tested as well as my grandson. There are apparently quite a few antigenic things that can be running around on the surface of your red blood cells. My question is will my son have any Kell at all? Thank you again, this has been a struggle for many years to figure out what all this means. O positive blood type is about 37% in Caucasians, 47% in African American, 53% in Hispanic, and 39% in Asian. If you are more worried than you are in love, then end the relationship. I work in a blood bank, this is NOT true. I didn’t find out until i was preganat with my second child five years later. Does that mean I got this from my parents? I’m pretty sure at least a few of the generations had multiple siblings of both genders. I wish we had the $ for the full bloodwork for my husband, as we are only finding put of he is positive or negative for the antigens. I hope that helps. Also, if a baby is cellano-negative (which it might very well be and indeed probably is) then the body won’t attack the fetus; your antigens won’t “see” anything there to attack. Either the Kell did not ‘turn on’ and make itself known, or your mom’s body doesn’t have a profound alloimmunizational response. First, I think s/he is correct about your blood work being normal. If those offspring marry blue-eyed (bb) people, then more of the grandkids will be blue-eyed too. To have Kell positive blood means you have at least one of the Kell antigens on your red blood cells. Yes. how? I am so sorry about the delayed reply. I’m still confused about the Kk vs. KK terminology. The ABO gene found on chromosome 9 determines the ABO blood group system. If you live where you have access to an obstetrician, then there is a lot they can do to make any subsequent kell-effected pregnancies go well. Thank you for clearing up all of these things and I appreciate the guidance about having my kids tested. The good news is that a simple test will tell you if your son has it … and the better news is that I think it is highly unlikely. I am so very, very sorry for the loss of your triplets. Does this mean anything for the Kell and other antibodies/antigens? My ob/gyn also informed me it was not a good idea to have any other pregnancies, and when I had my first back surgery I had to donate blood for myself to be stored. My husband has been tested and he is Negative for K (Kell), positive for k (cellano). Okay, I’m trying to remember science in middle school, having a tough time. … Prior to the test I was told that I would have the antigens (or antibodies) because my wife was reacting to them from blood from the prior babies / umbilical cord getting into her system from the prior C Sections and that the effectively half of the foreign blood came from me as the kids were a mix of my and my wife’s blood. Bc my antibodies no longer titered my OB did NOT want to do an amnio to determine if my baby was K+. HOWEVER, just being from England (which the name Cary is) means your ancestors had a 9% chance of carrying the gene. Okay, the GOOD news is that as a K+ woman your pregnancies will never be effected. This is in addition to the ABO blood groups that most people know about. but he is also conserned on how his family will twist this around since we dont know much about this anti-body. The Kell factor refers to an antigen that’s attached to the membrane of red blood cells. Okay, let’s call the Kell positive allele “K” and the Kell negative gene “k”. Could I get severe anemic? Am I at any risk myself during my pregnancy? The ABO gene found on chromosome 9 determines the ABO blood group system. It will be a normal pregnancy, like your last one. If you get pregnant again you need to be referred to a high risk doctor by 12 wks. This does not, sadly, rule out any other disaster — but from the Kell end of things you should be fine. Thank you. The Kell factor refers to an antigen that’s attached to the membrane of red blood cells. I have three children. Yay! If #9 is a boy, every pregnancy after his wife’s first will need to be watched by an OB/Gyn who knows she might be carrying a Kell+ fetus — unless his wife is K+ too, which is rare. They did a titer all they told me was that it is an 8 ?…. Those antigens can doge a test more than people realize. My second child, my son, had mild haemolytic disease of the newborn. I became Kell antigen positive after receiving a blood transfusion while giving birth. Thanks in advance for any insight you can provide. I wish I could be of more help, but I am not a medical doctor … I just study the culture of medicine. Not only Rh-, m-n- and KK? Hi, I’m an anthropologist, and maybe a specialist in genetic transmission could help you. Any of your children could be Kk because as a Kell positive mom, your body wouldn’t harm them with or without the Kell gene. Any ideas on where the pos K people are from?? Since my blood is so rare, should they be concerned, and is this something they need to have checked? My titers have been low… So everything is fine. However, if you have a Kell+ son and his future partner is Kell- then they need to give her a doctor a heads up when/if she gets pregnant. Can anyone please shed some light on whether I have antigens or antibodies. So does that mean that the baby 100% will not have it and I don’t have to worry about a single thing? Secondly, when Kell positive people with the typical Kk genotype reproduce with one of the Kell negative (kk) majority, each child has only a 50/50 chance of being Kell positive. If you had the antigens, it would just mean you are Kell positive and it would pose no threat to your pregnancy, but antibodies mean that your blood has been exposed to the Kell proteins. A little bit about the Kell positive blood type, on A little bit about the Kell positive blood type, Click to email this to a friend (Opens in new window), Click to share on Facebook (Opens in new window), Click to share on LinkedIn (Opens in new window), Click to share on Reddit (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Tumblr (Opens in new window), Click to share on Pinterest (Opens in new window), Click to share on Pocket (Opens in new window), Click to share on Telegram (Opens in new window), Click to share on WhatsApp (Opens in new window), Click to share on Skype (Opens in new window), http://www.sciencealert.com/artificial-blood-could-be-used-in-trial-transfusions-by-2016. Will this be a health problem for me later in life. How do we know that if he was Kell positive, Henry had to be Kk and not KK? And even if he DID have the Kell gene, there is lots they could do for his future reproductive partner, and many people with K+ men get lucky and get 3 Kell negative babies in a row. Your body won’t attack a Kell+ baby because it is the SAME and it won’t attack a Kell- baby because there is no antigen there to set it off. Baby 3 I had to have a c sec and transfusion. Thanks for writing back and for explaining how the Kell blood type will effect me. If the baby does have the cellano gene, then your titers will start to show it and the doctors can respond as needed. After my first born I had a transfusion that obviously contained the Kell antibodies. I would say that the testing for C e were antigen testing so they were positive which means you cannot make antibodies to those antigens, I have anti Kell antibodies from a blood transfusion I had after the birth of my twins. and where that came from? If he is actually heterozygous (Kk) then yes, you were VERY lucky but not beyond rational expectations. I just have a biology degree and study doctors. Titers of 1:8 or higher are considered critical for Kell. My kids were all blood typed as O+. Kell is not a blood type it is antigen found on the red blood cell. This is in addition to the ABO blood groups that most people know about. The baby is ok, but now I’m really worried about my next pregnancies. I hope your two Kell positive sons’ future reproduction will be lucky and their partners are successfully treated by modern OBs if the babies get the K gene! I am anti-k (lowercase) so it is kind of like a cousin to Kell. Most OB/Gyns won’t be looking for this problem, because it doesn’t come up all that often. He had some jaundice, and was in an incubator for awhile, but it wasn’t too serious. However, it is the third most common blood type which is present in about 1 out of 12 individuals. It could be prevented if they would just screen. If the fetus is Kell- then there is no antigen there to cause your body to have alloimmunization. Your body recognized the foreign part of the blood (Kell) and built up antibodies to get rid of it… In the same way your body builds up antibodies to get rid of an infection. Would I be safe assuming that my first daughter would be kk and my son kk and my youngest child Kk ? The Kell antigen system (or the Kell-Cellano system) was named after the family of the antibody producer Mrs. Kellacher. I am anti-k (little k, used to be called cellano). My third child, another daughter was born with no issues whatsoever. I am sure your physician will take excellent care of you. At 33 weeks, she is with the range of viability so even if your body starts attacking they can induce your labor and ‘rescue’ her from a hostile uterine environment. Continue to take steps to protect yourself. I think it would have to be a deficient immune response by your own body and I have no knowledge about that topic. For this reason, Kell typing of the father is the primary step in the management of Kell disease in pregnancy. You’re actually Kk, which means you have a Kell+ gene and one without it. See? We have been trying for years to have a 2nd baby, I have had several misscarriages so those were probably Kell positive babies. My husbands waiting to get results to find out if he is kell pos. For simplicity’s sake we’ll say brown eyes are “B” and blue eyes are “b”. (Ack! Seriously, and no sugarcoating, there is no real reason to think the kids aren’t biologically your progeny. (Yes, even five in a row. Le système Rhésus est un système complexe qui comporte plusieurs antigènes dont le plus important pour la transfusion est l’antigène D. Sur les globules rouges des sujets dits Rhésus négatifs l’antigène D n’est pas présent alors qu’il l’est chez les sujets Rhésus positif. Today my husbands blood work came back as negative just as your husbands did. They’ll need to get tested, because your daughters will have no reproductive issues, if your son has the Kk then his reproductive partner’s Ob/Gyn will need to know to keep a close eye on her pregnancies. I have had two healthy pregnancies – with my first being a girl and my second being a boy. My older sister and my younger half-brother and I all inherited his Kell. This post will provide a tad more information as to what it is exactly and how it is transmitted. Un groupe sanguin comprend une lettre A, B ou O et un signe + ou –. I am wondering, can two positive kell people have children together? So no, it is not rare. … If he has kk, then it’s all clear because he cannot give any offspring the Kell antigen gene. In Blood Will Tell I talked about the theory that Henry VIII had a Kell positive blood type, but in my quest to prevent innocent readers from slipping into an over-science coma I didn’t go into deep detail about it. What this means is you can place your iPhone on a wireless charging pad and the iPhone would charge wirelessly without having to connect a charger. I will not be having any more children, but am concerned that it may be an issue for them when they have children. I am have developed anit kell anit bodies I think for a blood transfusion I had way back in 2003 .my question is I have 7 children all from the same dad The Kell blood type system is highly polymorphic, meaning that there are many different alleles (alternative forms of a gene) - about 25! What are some viable reasons these antigens could be in her system? yesterday we just came back from my 2nd visit to a specialist. Not sure if you are Kell Positive or Anti-K. When my husbands blood came back, he is kell negative. If you go for a third or more, there is some risk and make sure you let your OB/Gyn know you have the Kell antibodies. Please understand, I have thought long and hard about this before posting… whatever the answer, the outcome will not end my marriage. Thank you for the information it is helpful, I don’t know this helps when I had my first sugrey the hospital sent me this card and it reads: ABO GROUP:A, RH TYPE: POSITIVE, ATYPICAL ANTIBOTIES:K (uppercase). Actually I checked to be notified by email of follow up comments do we’re good. Even if he does happen to be kell positive (very unlikely) then your baby will still be safe since you don’t have anti-kell antibodies. Well, tune in next post for the exciting adventures of Genealogy Quest! An RhD positive baby will only have rhesus disease if their RhD negative mother has been sensitised to RhD positive blood. I know this because the pregnancy and baby were completely normal.i am expecting again and dad has not been tested yet.i was just wondering if there is a chance he could be kell postive after 7 healthy pregnancy and babies .all same dad? Your husband would be the one who is Kell positive. I’m 35 weeks and I found out about two weeks ago that my original bloodwork was positive for the anti kell. Would my body make the anti-kell show up even if daddy is negative? However, I am currently pregnant and am wondering how it could possibly effect my pregnancies. I hope your wife is anti-Kell antigen-free and all proceeds smoothly with a healthy, happy baby! PLEASE let me know what the results were if you get a son tested for Kell!! If you are antigen typed and are Kell positive this means you cannot make a antibodies to Kell. A Kell positive man can cause serious problems for his reproductive partners after the first pregnancy, because a Kell negative mother’s body will develop a Kell alloimmunization — which means that her body would attack a Kell positive fetus as “foreign” and the result is fetal or neonatal death. I’m sure a proper medical doctor would be able to figure it out. The BAD news is that if either of your sons have your blood type then their partners might (and it is a big if considering genetics) have issues IF the partner is a normal K- and IF the second fetus is K+. Also, there are HUNDREDS of antigens a partner could pass to baby that mother doesn’t have– many in the Rh system, Kell system, Kidd system, Duffy, Dombrock, etc. I say that it’s more look like a woman with a blood type of “-” marrying a man with blood type “+”. It’s not usually tested for, and yet look at the damage it can do! If your baby appears severely affected, blood transfusions, given to your baby while he’s still in utero, can help prevent harm to baby. I was diagnosed Kell positive when I was in my 20.’ My wife at the time had 6 miscarriages. I hope you get good news!! Basically, every time a Kk person has a male child, the odds of the K gene making it to the next generation is lessened. I’m already on weekly appointments. O genes … It can be used in many aspects, referring to: what, how much or how high one gets. What I’m not clear on is whether this means I was kell positive from birth and therefore my pregnancy won’t be affected, or kell positive for anti-antigens which I may have picked up from a transfusion during surgery 20 years ago. The person who proposed to my has the blood type O+ but with kell antigens Our mothers are both O+ Kell-. I’d love to find it. First, homozygous Kells (KK) is very, very rare. This is how immunohematology is performed on the antigen antibody reaction. Synopsis. Let’s look at the hypothetical example wherein a Kk/kk couple has four children to see what can happen: 1) They have no K postive offspring. so far me and my husband who is the father to both of my children, are barely finding out information on this. I hope this pregnancy and any future pregnancies go smoothly and without complications! Your daughter should have no issues (related to blood type) and your son’s partner (if he chooses to have kids as adult and falls in love with a reproductively viable woman!) Is Kell only spread by the men? Now almost 4 years later I’m 35wks and just finding out that I have this Kell antigen. We also don’t know if the baby is definitely negative if antibodies have shown up in the first place…. The babies who had mild jaundice did so most likely because of the “big” antigen groups — A or B. Ok, yes I had it backwards. Early delivery might also be necessary. This means approximately 35.7% of the population has an A positive blood. Or if I get pregnant again will it come back? We won’t know if he is heterozygous or homozygous, but hopefully he will be negative and that will be the end of it. You are a rare case, but obviously that does happen. He is 100% the father as well. No trouble during that pregnancy. I am so sorry. During a transfusion or delivery if that person is exposed to the antigen then antigen antibody Reaction occurs. Le signe + ou - correspond au rhésus. First, I am sorry for the loss your brother and SIL went through. Wait another 3 … Plasma contains antibodies. I’ve heard stories of Kell making you severely anemic, and causing women to bleed out even in cases where baby is negative. Great strides have been made to help Alloimmunization in pregnancy. Me, and ALL of my family, sis, mom, aunts are all K pos, because a blood company wanted us to give blood for money to make diagnostics……. Longer and be harder more hospitals with my first instinct is to wonder if you got a false.! 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